The present research work aimed at evaluation of Tara gum (TG) as a controlled release and mucoadhesive agent in buccal tablets. Buccoadhesive tablets were formulated with an intention to avoid hepatic first-pass metabolism and also to enhance residence time in the buccal cavity. TG was procured from the market and characterized for various physiochemical parameters as well as for its adhesive properties. Tablets were prepared containing TG and chlorpheniramine maleate (CPM) as a model drug, using direct compression technique. Nine different formulations were prepared and evaluated containing three mucoadhesive components namely Carbopol 974P, Methocel K4M and TG (25 mg, 50 mg and 75 mg). The results of the study indicated that the TG had good physicochemical and morphological characteristics. Tablets conformed to the Pharmacopoeial specifications and in-vitro release studies showed the controlled action of drug with increasing concentration of the TG in the formulations. Permeability studies revealed that drug permeation was increased with the increase in the concentration of the mucoadhesive polymer. FTIR and UV spectroscopy studies between gum and CPM suggested the absence of chemical interaction between CPM and TG. The formulated mucoadhesive tablets for buccal administration containing natural TG (TGF3) have a potential for the controlled action of drug release. Thus, buccoadhesive tablets for controlled release were successfully formulated using natural gum.
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